A study reported on CavalierHealth.org states that Cavaliers have higher levels of deleterious genetic variations, compared to seven other breeds. This is a pilot study and the researchers do air caution saying, "... although cKCs have accumulated deleterious alleles that are likely to have large phenotypic effects, the total number of added mutations may be relatively low and it may hence be premature to use our results as an argument to discourage further breeding of cKCs."
The interesting bit for me is the bit about gene NEBL in papillary muscles, where they say, "The most common disease in cKCs is myxomatous mitral valve disease (MMVD). To identify variants linked to this disease we next characterize mutations that are common in cKCs, but rare in other breeds, and then investigate if these mutations can predict MMVD in dachshunds. We find that variants that regulate the expression of the gene NEBL in papillary muscles may increase the risk of the disease, indicating that loss of papillary muscle integrity could contribute to the development of MMVD."
PLOS have published the whole study and you can read the study HERE
Breeding active, sporting, sound little spaniels
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“Humans are aware of very little, it seems to me, the artificial brainy side of life, the worries and bills and the mechanisms of jobs, the doltish psychologies we've placed over our lives like a stencil. A dog keeps his life simple and unadorned.” Brad Watson, Last Days of the Dog-Men: Stories
Welcome to this blog. I am Jane, a hobby breeder, situated in North Devon, England, UK (map at bottom of page ,shows where we are) on a quest to breed a healthier type Cavalier King Charles(small) type Spaniel.
WE DO NOT EXPORT PUPPIES
Why I don't export
Our breeding dogs are multi generational extensively health tested. With all our breeding stock having recommended and relevant DNA tests for their breed/breeds. We also have breeding stock annually eye examined on the BVA Hereditary Eye Disease Scheme for dogs, MRI scanned on the BVA scheme using the BVA chiari malformation /syringomyelia breeding protocol, and heart examined using The Kennel Club Heart Scheme for Cavalier King Charles breeding protocol